Abstract | OBJECTIVE: Our previous study revealed that chronic consumption of a high-fat diet (HFD) stimulates colon cancer progression in obesity-resistant BALB/c mice. The aim of the present study was to investigate the significant alteration of metabolites caused by tumor progression and an HFD in the serum and liver in the same mouse model. METHODS: Male BALB/c mice were fed either a control diet or a HFD for 20.5 wk. The syngeneic CT26 colon carcinoma cells were injected into the right rear flank of mice after 16 wk of feeding. Metabolites in serum and liver samples were analyzed by ultra-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry-based metabolomics. RESULTS: CONCLUSION: The HFD- and tumor-related metabolite alterations of phospholipids, especially lysoPCs, in the liver and serum of obesity-resistant mice, suggesting that the lysoPCs are potential biomarkers for the chronic consumption of HFD in nonobese individuals.
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Authors | Hyang Yeon Kim, Minhee Kim, Hye Min Park, Jiyoung Kim, Eun Ji Kim, Choong Hwan Lee, Jung Han Yoon Park |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
2014 Nov-Dec
Vol. 30
Issue 11-12
Pg. 1433-41
ISSN: 1873-1244 [Electronic] United States |
PMID | 25280424
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Dietary Fats
- Lysophosphatidylcholines
- Lysophospholipids
- lysophosphatidylethanolamine
- lysophosphatidic acid
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Topics |
- Animals
- Colonic Neoplasms
(blood, metabolism)
- Diet, High-Fat
- Dietary Fats
(blood, metabolism)
- Liver
(metabolism)
- Lysophosphatidylcholines
(blood, metabolism)
- Lysophospholipids
(blood, metabolism)
- Male
- Mice, Inbred BALB C
- Obesity
(metabolism)
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