HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Analysis of mixed lymphocyte-tumor culture in patients with malignant brain tumor.

Abstract
To ascertain whether tumor-specific immune response occurs in patients with malignant brain tumors, lymphocyte blastogenetic responses to tumor cells were examined in 18 patients prior to operation and other treatment. Among 12 patients with malignant glioma, the peripheral blood lymphocytes (PBL's) showed a positive blastogenetic response to their own glioma cells in seven (58.3%), whereas the tumor-infiltrating lymphocytes (TIL's) showed a positive response in only three (25%). In four (66.7%) of six patients with metastatic brain tumors, however, both the PBL's and TIL's showed a positive blastogenetic response to their own tumor cells. In these four patients, this lymphocyte blastogenetic response to tumor cells were at a much lower level compared with phytohemagglutinin P or allogeneic lymphocyte stimulation. Furthermore, these responses were increased when the cells were cultured with interferon-gamma (500 U). Other lymphokines had no effect on the response. This method appears to be useful in identifying the tumor-specific immune response in patients with malignant brain tumor.
AuthorsS Yoshida, R Tanaka, M Ono, N Takai, T Saito
JournalJournal of neurosurgery (J Neurosurg) Vol. 71 Issue 3 Pg. 398-402 (Sep 1989) ISSN: 0022-3085 [Print] United States
PMID2527972 (Publication Type: Journal Article)
Chemical References
  • Interleukin-2
  • Picibanil
  • Interferon-gamma
Topics
  • Adolescent
  • Adult
  • Aged
  • Antibody Formation
  • Brain Neoplasms (immunology, pathology, secondary)
  • Glioma (immunology, pathology, secondary)
  • Humans
  • Interferon-gamma (pharmacology)
  • Interleukin-2 (pharmacology)
  • Lymphocyte Culture Test, Mixed
  • Lymphocytes (immunology)
  • Middle Aged
  • Picibanil (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: