Abstract | OBJECTIVE: METHODS: From 2000 to 2005, we analyzed tissue samples from 135 cases of TNBC obtained from curative surgeries at the Severance Hospital, Seoul, South Korea. Immunochemical staining for redox proteins was performed. RESULTS: The median patient age was 48 (range 27-76) years. TNM staging was as follows: T1 (n = 52, 38.5%), T2 (n = 81, 60%), T3 (n = 2, 1.5%), N0 (n = 88, 65.2%), N1 (n = 35, 25.9%), N2 (n = 8, 5.9%) and N3 (n = 4, 3.0%). Median follow-up was 59 (range 12-99) months. The high-expression catalase group tended to have a lower N stage (p = 0.016), lower tumor recurrence (p = 0.02) as well as longer overall survival rates (p = 0.05). After adjusting for patient age as well as tumor and nodal stage, we found that primary breast cancers with high catalase expression levels did not have an improved clinical outcome. A high MTC4 expression in the stroma was strongly associated with increased manganese superoxide dismutase expression (p = 0.015) and a significantly longer overall survival (p = 0.032). CONCLUSION: Considering the lack of targeted molecules as well as molecular heterogeneity of TNBC, ROS markers may provide clues to clinical outcome in TNBC.
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Authors | Darae Kim, Ja Seung Koo, Soohyeon Lee |
Journal | Oncology
(Oncology)
Vol. 88
Issue 1
Pg. 9-17
( 2015)
ISSN: 1423-0232 [Electronic] Switzerland |
PMID | 25277241
(Publication Type: Journal Article)
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Copyright | © 2014 S. Karger AG, Basel. |
Chemical References |
- Monocarboxylic Acid Transporters
- Muscle Proteins
- Reactive Oxygen Species
- SLC16A4 protein, human
- Catalase
- Superoxide Dismutase
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Topics |
- Adult
- Aged
- Catalase
(metabolism)
- Female
- Humans
- Middle Aged
- Monocarboxylic Acid Transporters
(analysis)
- Muscle Proteins
(analysis)
- Neoplasm Staging
- Prognosis
- Reactive Oxygen Species
(metabolism)
- Superoxide Dismutase
(analysis)
- Triple Negative Breast Neoplasms
(metabolism, mortality, pathology)
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