[Purpose] To evaluate the oxidative stress parameters and urinary
deoxypyridinoline levels in geriatric patients with
osteoporosis. [Subjects and Methods] Eighty geriatric patients aged over 65 years were recruited. Patients were divided into two groups: Group 1 (n=40) consisted of patients with
osteoporosis, and Group 2 (n=40) consisted of patients without
osteoporosis. Bone mineral density measurements were performed for all patients using DEXA. Oxidative stress parameters were analyzed in blood samples, and
deoxypyridinoline levels were analyzed in 24-hour urinary samples. [Results] Compared to Group 2, the total
antioxidant status and oxidative stress index levels of Group 1 were not significantly different; however, total
oxidant status and 24-hour urinary
deoxypyridinoline levels were significantly higher. Pearson correlation coefficients indicated that OSI and urinary
deoxypyridinoline levels were not correlated with any biochemical parameters. ROC-curve analysis revealed that urinary
deoxypyridinoline levels over 30.80 mg/ml predicted
osteoporosis with 67% sensitivity and 68% specificity (area under the curve = 0.734; %95 CI: 0.624-0.844). [Conclusion] Our results indicate that oxidative stress would play a role in the pathogenesis of
osteoporosis, and that urinary
deoxypyridinoline levels may be a useful screening test for
osteoporosis.