Effects of chronic heart failure on the responsiveness to angiotensin I and to angiotensin converting enzyme inhibition with cilazapril in rats.

Abstract

1. The effects of heart failure due to chronic myocardial infarction on the responsiveness to injected angiotensin I and ACE inhibition by intravenous cilazapril (1 mg kg-1) were evaluated. 2. For this purpose one group of 17 rats with a 4-week old myocardial infarction was compared with a group of 10 sham operated rats. 3. Heart failure increased markedly the responsiveness of the renal and mesenteric vascular beds to ACE inhibition which produced a vasodilation in these two vascular beds. 4. This increased responsiveness was most likely due to a stimulation of the renin-angiotensin system without any change of sensitivity to angiotensin I of the renal and mesenteric vascular beds. 5. Cilazapril produced the same level of ACE inhibition in both groups of rats.

• Authors: J P Clozel
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 27 Suppl 2 Pg. 167S-174S ( 1989) ISSN: 0306-5251 [Print] England
• PMID: 2527530 (Publication Type: Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Pyridazines
• Cilazapril
• Angiotensin I

Topics

• Angiotensin I (pharmacology)
• Angiotensin-Converting Enzyme Inhibitors (pharmacology)
• Animals
• Chronic Disease
• Cilazapril
• Heart Failure (pathology, physiopathology)
• Hemodynamics (drug effects)
• Myocardial Infarction (enzymology, physiopathology)
• Myocardium (pathology)
• Pyridazines (pharmacology)
• Rats
• Rats, Inbred Strains
• Vascular Resistance (drug effects)