Abstract |
1. The effects of heart failure due to chronic myocardial infarction on the responsiveness to injected angiotensin I and ACE inhibition by intravenous cilazapril (1 mg kg-1) were evaluated. 2. For this purpose one group of 17 rats with a 4-week old myocardial infarction was compared with a group of 10 sham operated rats. 3. Heart failure increased markedly the responsiveness of the renal and mesenteric vascular beds to ACE inhibition which produced a vasodilation in these two vascular beds. 4. This increased responsiveness was most likely due to a stimulation of the renin-angiotensin system without any change of sensitivity to angiotensin I of the renal and mesenteric vascular beds. 5. Cilazapril produced the same level of ACE inhibition in both groups of rats.
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Authors | J P Clozel |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 27 Suppl 2
Pg. 167S-174S
( 1989)
ISSN: 0306-5251 [Print] England |
PMID | 2527530
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Pyridazines
- Cilazapril
- Angiotensin I
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Topics |
- Angiotensin I
(pharmacology)
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Animals
- Chronic Disease
- Cilazapril
- Heart Failure
(pathology, physiopathology)
- Hemodynamics
(drug effects)
- Myocardial Infarction
(enzymology, physiopathology)
- Myocardium
(pathology)
- Pyridazines
(pharmacology)
- Rats
- Rats, Inbred Strains
- Vascular Resistance
(drug effects)
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