Effect of Wnt inhibitors in pancreatic cancer.

Abstract

BACKGROUND/AIM:

Activated Wnt signaling in cancer cells leads to cell proliferation. It has been shown that the Wnt pathway is activated in pancreatic adenocarcinoma cells. Therefore, we tested the effect of Wnt inhibitors in human and murine pancreatic cancer cell lines.

MATERIALS AND METHODS:

The Wnt inhibitors ethacrynic acid (EA), ciclopirox olamine (CIC), piroctone olamine (PO) and griseofulvin (GF) were tested in murine and human pancreatic cancer cell lines with the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) assay.

RESULTS:

We showed that the Wnt inhibitors significantly reduced cell viability in murine, as well as human pancreatic cancer cell lines.

CONCLUSION:

These results may lead to a new therapeutic option with Wnt inhibitors for patients with pancreatic adenocarcinoma.

• Authors: Ilona Wall, Ingo G H Schmidt-Wolf
• Journal: Anticancer research (Anticancer Res) Vol. 34 Issue 10 Pg. 5375-80 (Oct 2014) ISSN: 1791-7530 [Electronic] Greece
• PMID: 25275031 (Publication Type: Journal Article)
• Copyright: Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Antineoplastic Agents
• Drug Combinations
• Ethanolamines
• Pyridones
• Wnt Proteins
• Ciclopirox
• Griseofulvin
• piroctone olamine
• Ethacrynic Acid

Topics

• Antineoplastic Agents (pharmacology)
• Cell Line, Tumor
• Ciclopirox
• Drug Combinations
• Ethacrynic Acid (pharmacology)
• Ethanolamines (pharmacology)
• Griseofulvin (pharmacology)
• Humans
• Pancreatic Neoplasms (metabolism)
• Pyridones (pharmacology)
• Wnt Proteins (antagonists & inhibitors, metabolism)
• Wnt Signaling Pathway (drug effects)