Abstract | INTRODUCTION: Recent research suggests a relationship of inflammatory bowel disease (IBD) and depression. Our objective was to evaluate for improvement of depressive symptoms with treatment of IBD using immunosuppressive medications. METHODS: RESULTS: Sixteen patients with UC and 53 patients with CD (all with active disease symptoms) were evaluated over a 60 day median follow-up evaluation (range 30, 140 days). Twenty-two patients started on immunomodulator therapy, and 47 patients started on anti-TNF therapy. Crohn's disease patients had significantly decreased PHQ-9 scores at follow-up [median 9 (range 3, 14) to 4 (1, 8)], with significant decreases only in those started on anti-TNF therapy. Changes in PHQ-9 and CRP were correlated (ρ = 0.38, p < 0.05). In patients with UC, PHQ-9 scores [5 (3, 9) to 2 (0, 5)] were significantly decreased. Percentage at risk of moderate to severe depression (PHQ-9 scores ≥10) was lower after treatment [ Crohn's disease 51-18 % (p < 0.05), ulcerative colitis 18-0 %]. CONCLUSION: Depressive scores decreased significantly in patients with IBD treated with immunosuppressive therapy and the number at risk for moderate to severe depression improved significantly.
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Authors | Sara Horst, Andrew Chao, Michael Rosen, Anne Nohl, Caroline Duley, Julianne H Wagnon, Dawn B Beaulieu, Warren Taylor, Lawrence Gaines, David A Schwartz |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 60
Issue 2
Pg. 465-70
(Feb 2015)
ISSN: 1573-2568 [Electronic] United States |
PMID | 25274158
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Tumor Necrosis Factor-alpha
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Topics |
- Adolescent
- Adult
- Aged
- Colitis, Ulcerative
(complications, diagnosis, drug therapy, immunology, psychology)
- Crohn Disease
(complications, diagnosis, drug therapy, immunology, psychology)
- Depression
(diagnosis, etiology, immunology, psychology)
- Female
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Middle Aged
- Predictive Value of Tests
- Psychiatric Status Rating Scales
- Retrospective Studies
- Risk Factors
- Severity of Illness Index
- Surveys and Questionnaires
- Time Factors
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors, metabolism)
- Young Adult
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