Abstract | AIMS: To investigate the regulating effects of catalpol on the hypothalamic-pituitary- adrenocortical-axis (HPA) in an Alzheimer's disease (AD) rat model. METHODS: RESULTS: Serum HYD level was significantly increased (p < 0.01), and both ACTH and CRH were dramatically decreased (p < 0.01) in the AD model group rats compared with normal control rats at day 7. Catalpol treatment was able to improve the hormone secretion disorder in AD model group rats compared with the model group (p < 0.01 or p < 0.05) in particular at 21 days. Structure damage of hypothalamus in the AD rat as evidenced less CRHR1 positive neurons, rough endoplasmic reticulum dilation and degranulation, and mitochondrial swelling under electron microscope. Catalpol treatment at both high and low doses was able to alleviate the structure damage of the hypothalamus in the AD rats. CONCLUSIONS:
Catalpol could improve the endocrine function of the HPA and alleviate the structural damage of hypothalamus in AD rats.
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Authors | Jin-Hong Wang, Wen-Tao Li, Shu-Tian Yu, Hai Xie, Hui-Rong Han |
Journal | Die Pharmazie
(Pharmazie)
Vol. 69
Issue 9
Pg. 688-93
(Sep 2014)
ISSN: 0031-7144 [Print] Germany |
PMID | 25272941
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Iridoid Glucosides
- Receptors, Corticotropin-Releasing Hormone
- catalpol
- Corticotropin-Releasing Hormone
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Topics |
- Alzheimer Disease
(drug therapy, physiopathology)
- Animals
- Corticotropin-Releasing Hormone
(blood)
- Enzyme-Linked Immunosorbent Assay
- Hippocampus
(pathology)
- Hypothalamo-Hypophyseal System
(drug effects, pathology)
- Hypothalamus
(pathology)
- Immunohistochemistry
- Iridoid Glucosides
(pharmacology)
- Microscopy, Electron, Transmission
- Neurons
(metabolism)
- Pituitary-Adrenal System
(drug effects, pathology)
- Rats
- Receptors, Corticotropin-Releasing Hormone
(biosynthesis)
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