Abstract | OBJECTIVE: METHODS: The volume of saliva secreted without stimulation was measured in patients with asthma or chronic obstructive pulmonary disease ( COPD) who also answered a questionnaire on subjective ratings for hoarseness. The relationship between salivary secretion and hoarseness was analyzed by the Pearson correlation and multiple linear regression. The prediction accuracy of salivary secretion for the grade of hoarseness was evaluated using a receiver-operating characteristic (ROC) analysis. RESULTS: A total of 232 patients participated in this study. The subjective rating score of hoarseness was negatively correlated with the volume of saliva secreted (r = -0.273, p < 0.001). A stepwise multiple linear regression analysis revealed that salivary secretion (p < 0.001) and the dose of fluticasone administered (p < 0.05) were significant variables for predicting hoarseness. The ROC analysis for predicting severe hoarseness by salivary secretion showed significant prediction accuracy (AUC = 0.690, 95% CI: 0.614-0.766, p < 0.001) and was higher in patients administered fluticasone (AUC = 0.732, 95% CI: 0.644-0.821, p < 0.001). CONCLUSIONS:
|
Authors | Daiki Hira, Setsuko Koshiyama, Yuko Komase, Nobuo Hoshino, Shin-Ya Morita, Tomohiro Terada |
Journal | The Journal of asthma : official journal of the Association for the Care of Asthma
(J Asthma)
Vol. 52
Issue 3
Pg. 296-300
(Apr 2015)
ISSN: 1532-4303 [Electronic] England |
PMID | 25272184
(Publication Type: Journal Article)
|
Chemical References |
- Adrenal Cortex Hormones
- Anti-Asthmatic Agents
- Bronchodilator Agents
|
Topics |
- Administration, Inhalation
- Adrenal Cortex Hormones
(adverse effects, therapeutic use)
- Adult
- Aged
- Aged, 80 and over
- Anti-Asthmatic Agents
(therapeutic use)
- Asthma
(drug therapy)
- Bronchodilator Agents
(therapeutic use)
- Female
- Hoarseness
(chemically induced)
- Humans
- Male
- Middle Aged
- Pulmonary Disease, Chronic Obstructive
(drug therapy)
- Quality of Life
- Salivation
(drug effects)
- Xerostomia
(chemically induced)
|