Functional polymorphisms of caveolin-1 variants as potential biomarkers of esophageal squamous cell carcinoma.

Abstract

OBJECTIVE:

To investigate the association of caveolin-1 (CAV1) genetic variants (C239A (rs1997623), G14713A (rs3807987), G21985A (rs12672038), T29107A (rs7804372)) with esophageal squamous cell carcinoma (ESCC) susceptibility.

METHODS:

A total of 427 patients with ESCC and 427 healthy controls were genotyped using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.

RESULTS:

There were significant differences between patients and controls in distributions of their genotypes and allelic frequencies in G14713A and T29107A polymorphisms. Furthermore, haplotype analysis revealed that haplotypes CAAT and CAGT were associated with high risk for ESCC, while haplotype CGGA was protective against ESCC. Stratified analysis showed the associations between the SNPs (G14713A and T29107A) and ESCC risk were noteworthy among female patients and patients who never smoke or drank alcohol.

CONCLUSIONS:

Genetic polymorphisms of CAV1 G14713A and T29107A might affect an individual's susceptibility in developing ESCC, making them efficient potential genetic biomarkers for early detection of ESCC.

• Authors: Shanshan Wang, Chuanzhen Zhang, Ying Liu, Changqing Xu, Ziping Chen
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 19 Issue 8 Pg. 652-9 (Dec 2014) ISSN: 1366-5804 [Electronic] England
• PMID: 25271040 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Caveolin 1
• DNA Primers

Topics

• Aged
• Base Sequence
• Biomarkers, Tumor (blood)
• Carcinoma, Squamous Cell (blood, genetics)
• Caveolin 1 (genetics)
• DNA Primers
• Esophageal Neoplasms (blood, genetics)
• Female
• Genetic Predisposition to Disease
• Haplotypes
• Humans
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length