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[Phosphate disorders: hyperphosphatemia or pseudohyperphosphatemia?].

Abstract
We report the case of a 79 year old woman presenting with progressive confusion and drowsiness. Renal insufficiency with hyperkalemia as well as hypercalcemia and severe hyperphosphatemia were diagnosed. Renal insufficiency improved with treatment. However, hyperphosphatemia persisted without apparent explanation. We discuss possible causes of hyper- and pseudohyperphosphatemia. Specifically, phosphate analysis may be disturbed by the paraproteins in patients with multiple myeloma, resulting in pseudohyperphosphatemia. We review the standard laboratory phosphate measurement and the mechanisms of interference with paraproteins.
AuthorsNicole Aeberhard, Christof Schild, Nicolas Rodondi, Christine Roten-Joss, Kristina Tänzler
JournalPraxis (Praxis (Bern 1994)) Vol. 103 Issue 20 Pg. 1203-6 (Oct 01 2014) ISSN: 1661-8157 [Print] Switzerland
Vernacular TitlePhosphat(verw)irrungen: tatsächlich «Hyper» oder nur «Pseudo»?
PMID25270750 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Immunoglobulin Light Chains
  • Immunoglobulin lambda-Chains
  • Phosphates
Topics
  • Aged
  • False Positive Reactions
  • Female
  • Humans
  • Hypergammaglobulinemia (blood, diagnosis)
  • Hyperphosphatemia (blood, diagnosis, etiology)
  • Immunoglobulin Light Chains (blood)
  • Immunoglobulin lambda-Chains (blood)
  • Multiple Myeloma (blood, diagnosis)
  • Phosphates (blood)

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