[Effects of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions].

Abstract

OBJECTIVE:

To investigate the effect of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions.

METHODS:

With Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum as the testing bacteria, the minimal inhibitory concentration (MIC) of cetylpyridinium chloride buccal tablets was determined using minute amount serial dilution test. The production of volatile sulfur compounds (VSCs) was measured using sulfide detector halimeter in the anaerobic bacteria culture at 4 and 8 h after addition of the tablets. The effect of the tablets in suppressing odor production by mouth-borne halitosis bacteria was assessed using cysteine challenge test in healthy volunteers, and the effectiveness was evaluated by measuring the reduction in VSCs production and the duration of the effect.

RESULTS:

Cetylpyridinium chloride buccal tablets inhibited the growth of all the 3 bacteria. The tablets obviously inhibited VSCs production by the 3 bacteria with a effect similar to chlorhexidine. Compared with distilled water gargle, the buccal tablets significantly reduced cysteine-induced VSCs production level in the healthy volunteers (P<0.05), and the effect lasted for 230 min.

CONCLUSION:

Cetylpyridinium chloride tablets can obviously suppress bacteria responsible for oral halitosis and produce good effects in the treatment of halitosis induced by oral conditions.

• Authors: Di Zhang, Chang-Hong Liu, Jincai Zhang, Dehong Cai, Xiaoyu Yang, Shiyi Li, Huilan Zhong
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 34 Issue 9 Pg. 1386-9 (Aug 2014) ISSN: 1673-4254 [Print] China
• PMID: 25263382 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Sulfur Compounds
• Tablets
• Volatile Organic Compounds
• Cetylpyridinium

Topics

• Cetylpyridinium (therapeutic use)
• Fusobacterium nucleatum (drug effects)
• Halitosis (drug therapy)
• Humans
• Microbial Sensitivity Tests
• Porphyromonas gingivalis (drug effects)
• Prevotella intermedia (drug effects)
• Sulfur Compounds (analysis)
• Tablets
• Volatile Organic Compounds (analysis)