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[Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance angiography combined with inflammatory factors for detecting atherosclerotic plaques in rabbits].

AbstractOBJECTIVE:
To investigate the feasibility of Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance angiography (USPIO-MRA) combined with interleukin-6 (IL-6) and IL-10 detection for detecting atherosclerotic plaques in rabbits.
METHODS:
Twenty-four normal male rabbits were randomly assigned (n=8) into group A with atherosclerosis induced by damaging the aortic tunica intima with Foley's tube in combination with a high fat diet, group B with a high fat diet, and group C without any intervention. At week 12, plain and USPIO-MRA was performed in all the 24 rabbits and the results were compared with pathological examinations; blood samples were collected from the ear vein to examine blood lipids and levels of IL-6 and IL-10.
RESULTS:
The rabbits in groups A and B showed significantly different IL-6 levels (167 ± 21.3 vs 116 ± 14.3 pg/ml, P<0.05) but comparable blood lipids and IL-10 levels (P>0.05). The levels of IL-6, IL-10, TC, TG, and LDL, but not HDL, differed significantly between groups A and C and between groups B and C (P<0.01). Continuous MRA scan showed significantly different signal-to-noise ratios (SNR) between the 3 groups.
CONCLUSION:
USPIO-MRA combined with IL-6 and IL-10 detection is feasible in detecting atherosclerotic plaques in rabbits.
AuthorsGongxin Li, Luzhao Wang, Peng Liu, Zhibo Wen, Fanheng Huang, Liheng Chen, Xin Zhao, Lin Lin, Yijun Zhou
JournalNan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 34 Issue 9 Pg. 1324-8 (Aug 2014) ISSN: 1673-4254 [Print] China
PMID25263368 (Publication Type: Journal Article)
Chemical References
  • Contrast Media
  • Dextrans
  • Interleukin-6
  • Magnetite Nanoparticles
  • ferumoxtran-10
  • Interleukin-10
Topics
  • Animals
  • Atherosclerosis
  • Contrast Media
  • Dextrans
  • Interleukin-10 (analysis)
  • Interleukin-6 (analysis)
  • Magnetic Resonance Angiography
  • Magnetite Nanoparticles
  • Male
  • Plaque, Atherosclerotic (diagnosis)
  • Rabbits

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