Abstract | OBJECTIVE: METHODS: Twenty-four normal male rabbits were randomly assigned (n=8) into group A with atherosclerosis induced by damaging the aortic tunica intima with Foley's tube in combination with a high fat diet, group B with a high fat diet, and group C without any intervention. At week 12, plain and USPIO-MRA was performed in all the 24 rabbits and the results were compared with pathological examinations; blood samples were collected from the ear vein to examine blood lipids and levels of IL-6 and IL-10. RESULTS: The rabbits in groups A and B showed significantly different IL-6 levels (167 ± 21.3 vs 116 ± 14.3 pg/ml, P<0.05) but comparable blood lipids and IL-10 levels (P>0.05). The levels of IL-6, IL-10, TC, TG, and LDL, but not HDL, differed significantly between groups A and C and between groups B and C (P<0.01). Continuous MRA scan showed significantly different signal-to-noise ratios (SNR) between the 3 groups. CONCLUSION:
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Authors | Gongxin Li, Luzhao Wang, Peng Liu, Zhibo Wen, Fanheng Huang, Liheng Chen, Xin Zhao, Lin Lin, Yijun Zhou |
Journal | Nan fang yi ke da xue xue bao = Journal of Southern Medical University
(Nan Fang Yi Ke Da Xue Xue Bao)
Vol. 34
Issue 9
Pg. 1324-8
(Aug 2014)
ISSN: 1673-4254 [Print] China |
PMID | 25263368
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- Dextrans
- Interleukin-6
- Magnetite Nanoparticles
- ferumoxtran-10
- Interleukin-10
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Topics |
- Animals
- Atherosclerosis
- Contrast Media
- Dextrans
- Interleukin-10
(analysis)
- Interleukin-6
(analysis)
- Magnetic Resonance Angiography
- Magnetite Nanoparticles
- Male
- Plaque, Atherosclerotic
(diagnosis)
- Rabbits
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