Predictive SNPs for radiation-induced damage in lung cancer patients with radiotherapy: a potential strategy to individualize treatment.

Abstract

In the treatment of lung cancer, radiotherapy has become one of the most important therapies, despite its sometimes unpredictable side effects. As such, identifying lung cancer patients who are at high risk of developing severe radiation-induced damage (mainly radiation pneumonitis and radiation-induced esophageal toxicity) and applying effect intervention or monitoring techniques are important. Although human diversity to a certain amount is explained by clinical and dosimetric factors, the presence of specific genetic determinants also influences the occurrence of radiation-induced damage. Here we summarize the data on mechanisms of radiation pneumonitis and radiation-induced esophageal toxicity supporting the involvement of variances of genes in the evolution of radiation-induced damage. Furthermore, the available evidence from current clinical studies of genetic polymorphisms for the prediction of radiation pneumonitis and radiation-induced esophageal toxicity is discussed. Eventually, this may help to truly individualize radiotherapy, using a personal genetic profile of the most relevant genes for each lung cancer patient.

• Authors: Qian Huang, Fangwei Xie, Xuenong Ouyang
• Journal: The International journal of biological markers (Int J Biol Markers) Vol. 30 Issue 1 Pg. e1-11 (Feb 24 2015) ISSN: 1724-6008 [Electronic] United States
• PMID: 25262703 (Publication Type: Journal Article, Review)

Topics

• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Lung Neoplasms (radiotherapy)
• Polymorphism, Single Nucleotide
• Precision Medicine
• Radiation Pneumonitis (genetics)
• Risk