Abstract | BACKGROUND:
Pesticide exposures are ubiquitous and of substantial public concern. We examined the potential association of congenital heart defects with residential proximity to commercial agricultural pesticide applications in the San Joaquin Valley, California. METHODS: Study subjects included 569 heart defect cases and 785 non-malformed controls born from 1997 to 2006 whose mothers participated in a population-based case-control study. Associations with any versus no exposure to physicochemical groups of pesticides and specific chemicals were assessed using logistic regression adjusted for relevant covariates, for 8 heart defect phenotypes that included ≥ 50 cases and pesticide exposures with ≥ 5 exposed cases and controls, which resulted in 235 comparisons. RESULTS: CONCLUSIONS: Most pesticides were not associated with increased risk of specific heart defect phenotypes. For the few that were associated, results should be interpreted with caution until replicated in other study populations.
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Authors | Suzan L Carmichael, Wei Yang, Eric Roberts, Susan E Kegley, Amy M Padula, Paul B English, Edward J Lammer, Gary M Shaw |
Journal | Environmental research
(Environ Res)
Vol. 135
Pg. 133-8
(Nov 2014)
ISSN: 1096-0953 [Electronic] Netherlands |
PMID | 25262086
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Agriculture
- California
(epidemiology)
- Environmental Exposure
(adverse effects, statistics & numerical data)
- Female
- Heart Defects, Congenital
(epidemiology)
- Humans
- Infant, Newborn
- Logistic Models
- Maternal Exposure
(adverse effects, statistics & numerical data)
- Odds Ratio
- Pesticides
(adverse effects)
- Pregnancy
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