Reduced resting-state brain activity in the default mode network in children with (central) auditory processing disorders.

Abstract

BACKGROUND:

In recent years, there has been a growing interest in Central Auditory Processing Disorder (C)APD. However, the neural correlates of (C)APD are poorly understood. Previous neuroimaging experiments have shown changes in the intrinsic activity of the brain in various cognitive deficits and brain disorders. The present study investigated the spontaneous brain activity in (C)APD subjects with resting-state fMRI (rs-fMRI).

METHODS:

Thirteen children diagnosed with (C)APD and fifteen age and gender-matched controls participated in a rs-fMRI study during which they were asked to relax keeping their eyes open. Two different techniques of the rs-fMRI data analysis were used: Regional Homogeneity (ReHo) and Independent Component Analysis (ICA), which approach is rare.

RESULTS:

Both methods of data analysis showed comparable results in the pattern of DMN activity within groups. Additionally, ReHo analysis revealed increased co-activation of the superior frontal gyrus, the posterior cingulate cortex/the precuneus in controls, compared to the (C)APD group. ICA yielded inconsistent results across groups.

CONCLUSIONS:

Our ReHo results suggest that (C)APD children seem to present reduced regional homogeneity in brain regions considered a part of the default mode network (DMN). These findings might contribute to a better understanding of neural mechanisms of (C)APD.

• Authors: Agnieszka Pluta, Tomasz Wolak, Natalia Czajka, Monika Lewandowska, Katarzyna Cieśla, Mateusz Rusiniak, Diana Grudzień, Henryk Skarżyński
• Journal: Behavioral and brain functions : BBF (Behav Brain Funct) Vol. 10 Issue 1 Pg. 33 (Sep 26 2014) ISSN: 1744-9081 [Electronic] England
• PMID: 25261349 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Auditory Perceptual Disorders (physiopathology)
• Brain (physiopathology)
• Brain Mapping
• Child
• Female
• Humans
• Image Processing, Computer-Assisted
• Magnetic Resonance Imaging
• Male
• Nerve Net (physiopathology)