Abstract |
Hepatocellular adenomas (HCAs) are heterogeneous group of benign tumors; three pathomolecular subtypes have been identified so far: hepatocyte nuclear factor 1 α-inactivated HCA (H-HCA) (35-40%), inflammatory HCA (I-HCA) (>50%), β- catenin activated HCA (10%). Ten percent of I-HCA are also β- catenin activated. We report a rare case of three histologically confirmed steatotic HCAs of three different phenotypes: I-HCA, β- catenin activated I-HCA, and H-HCA in a 36-year-old woman. This observation outlines that in the same patient, HCA may be of different subtypes. The predisposition to develop different HCA hypothetically caused by a "benign tumorigenic field effect" may result, even rarely, in different genotypes/phenotypes such as H-HCA and I-HCA. Moreover, we illustrate the very high specificity of MR for subtyping HCA.
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Authors | N Alberti, C Castain, A Crombe, N Frulio |
Journal | Clinics and research in hepatology and gastroenterology
(Clin Res Hepatol Gastroenterol)
Vol. 39
Issue 2
Pg. e17-22
(Apr 2015)
ISSN: 2210-741X [Electronic] France |
PMID | 25260568
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2014 Elsevier Masson SAS. All rights reserved. |
Topics |
- Adenoma, Liver Cell
(complications, genetics)
- Adult
- Fatty Liver
(complications)
- Female
- Humans
- Liver Neoplasms
(complications, genetics)
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