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Detection of vaccine-derived rotavirus strains in nonimmunocompromised children up to 3-6 months after RotaTeq® vaccination.

Abstract
We conducted a survey on the presence of RotaTeq vaccine viruses in infants hospitalized with respiratory infection, and detected shedding in 17% of children (<2 years of age) who had ever received the vaccine. The latest detection was at the age of 8 months. We conclude that asymptomatic long-time shedding of RotaTeq viruses is not uncommon, and is particularly associated with genotype G1.
AuthorsJukka Markkula, Maria Hemming, Timo Vesikari
JournalThe Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 34 Issue 3 Pg. 296-8 (Mar 2015) ISSN: 1532-0987 [Electronic] United States
PMID25260041 (Publication Type: Journal Article)
Chemical References
  • Antigens, Viral
  • Capsid Proteins
  • Rotavirus Vaccines
  • VP6 protein, Rotavirus
Topics
  • Antigens, Viral (genetics, immunology)
  • Capsid Proteins (genetics, immunology)
  • Female
  • Genotype
  • Humans
  • Infant
  • Male
  • Prospective Studies
  • Rotavirus (genetics, immunology)
  • Rotavirus Infections (prevention & control)
  • Rotavirus Vaccines (administration & dosage, immunology)
  • Vaccination

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