Curcumin, a natural antioxidant, acts as a noncompetitive inhibitor of human RNase L in presence of its cofactor 2-5A in vitro.

Abstract

Ribonuclease L (RNase L) is an antiviral endoribonuclease of the innate immune system, which is induced and activated by viral infections, interferons, and double stranded RNA (dsRNA) in mammalian cells. Although, RNase L is generally protective against viral infections, abnormal RNase L expression and activity have been associated with a number of diseases. Here, we show that curcumin, a natural plant-derived anti-inflammatory active principle, inhibits RNase L activity; hence, it may be exploited for therapeutic interventions in case of pathological situations associated with excess activation of RNase L.

• Authors: Ankush Gupta, Pramod C Rath
• Journal: BioMed research international (Biomed Res Int) Vol. 2014 Pg. 817024 ( 2014) ISSN: 2314-6141 [Electronic] United States
• PMID: 25254215 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• RNA, Double-Stranded
• Endoribonucleases
• 2-5A-dependent ribonuclease
• Curcumin

Topics

• Antioxidants (administration & dosage)
• Crystallography, X-Ray
• Curcumin (administration & dosage, chemistry)
• Endoribonucleases (antagonists & inhibitors, biosynthesis, chemistry)
• Gene Expression Regulation, Developmental (drug effects)
• Humans
• Immunity, Innate (drug effects)
• Molecular Docking Simulation
• Protein Conformation (drug effects)
• RNA, Double-Stranded (genetics)