Abstract | AIM: To determine the plasmatic iron content and evaluate the oxidative stress (OS) markers in subjects receiving blood therapy. METHODS: Thirty-nine individuals with unspecified anemia receiving blood transfusions and 15 healthy subjects were included in the study. Anemic subjects were divided into three subgrouP: (1) those that received up to five blood transfusions (n = 14); (2) those that received from five to ten transfusions (n = 11); and (3) those that received more than ten transfusions (n = 14). Blood samples were collected by venous arm puncture and stored in tubes containing heparin. The plasma and cells were separated by centrifugation and subsequently used for analyses. Statistical analyses were performed using Kruskal-Wallis analysis of variance followed by Dunn's multiple comparison tests when appropriate. RESULTS: CONCLUSION: Our data reveal that changes in OS markers are correlated with levels of labile plasmatic iron and ferritin and the number of transfusions.
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Authors | Marília Sabo Fernandes, Tatiana Tamborena Rissi, Luisa Zuravski, Juliana Mezzomo, Carmen Regla Vargas, Vanderlei Folmer, Félix Alexandre Antunes Soares, Vanusa Manfredini, Mushtaq Ahmed, Robson Luiz Puntel |
Journal | World journal of experimental medicine
(World J Exp Med)
Vol. 4
Issue 3
Pg. 38-45
(Aug 20 2014)
ISSN: 2220-315X [Print] United States |
PMID | 25254188
(Publication Type: Journal Article)
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