Immunohistological Description of Nongestational Ovarian Choriocarcinoma in Two Female Mice With Conditional Loss of Trp53 Driven by the Tie2 Promoter.

Abstract

Nongestational ovarian choriocarcinoma (NGCO) is a tumor of germ cell origin seldom described in nonhuman species. Few spontaneous cases are reported in macaques and mice, with the B6C3F1 strain overrepresented. This report describes 2 cases of ovarian choriocarcinoma in nulliparous female mice with conditional loss of Trp53 under the Tie2 promoter. The mouse line was maintained on a mixed genetic background including Crl: CD1(ICR) and 129X1/SvJ strains. In both cases, affected ovary was partially replaced by blood-filled lacunae lined by neoplastic trophoblast-like giant cells. Immunohistochemically, neoplastic cells expressed folate-binding protein and prolactin and were invariably negative for p53. To the authors' knowledge, this is the first report characterizing this entity in a genetically engineered mouse (GEM) line. Considering that germ cells (the cell population from which NGCO originates) constitutively express Tie2 receptor, it can be speculated that Tie2-driven deletion of Trp53 may have played a role in the development of these tumors.

• Authors: V Castiglioni, M Farhang Ghahremani, S Goossens, M De Maglie, M Ardizzone, J J Haigh, E Radaelli
• Journal: Veterinary pathology (Vet Pathol) Vol. 52 Issue 4 Pg. 752-6 (Jul 2015) ISSN: 1544-2217 [Electronic] United States
• PMID: 25253064 (Publication Type: Case Reports, Journal Article)
• Copyright: © The Author(s) 2014.

Chemical References

• Tumor Suppressor Protein p53
• Receptor, TIE-2
• Tek protein, mouse

Topics

• Animals
• Choriocarcinoma (pathology, veterinary)
• Female
• Immunohistochemistry (veterinary)
• Mice
• Mice, Inbred ICR
• Mice, Transgenic
• Neoplasms, Germ Cell and Embryonal (pathology, veterinary)
• Ovarian Neoplasms (pathology, veterinary)
• Pregnancy
• Receptor, TIE-2 (genetics)
• Tumor Suppressor Protein p53 (genetics)