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A novel protein glycan biomarker and future cardiovascular disease events.

AbstractBACKGROUND:
Glycosylated proteins partake in multiple cellular processes including inflammation. We hypothesized that GlycA, a novel biomarker of protein glycan N-acetyl groups, is related to incident cardiovascular disease (CVD), and we compared it with high-sensitivity C-reactive protein (hsCRP).
METHODS AND RESULTS:
In 27 491 initially healthy women, baseline GlycA was quantified by nuclear magnetic resonance spectroscopy and hsCRP by an immunoturbidimetric assay. During median follow-up of 17.2 years, 1648 incident CVD events occurred (myocardial infarction, ischemic stroke, coronary revascularization, and CVD death). GlycA and hsCRP were moderately correlated (Spearman r=0.61, P<0.0001). In Cox regression models that included age, ethnicity, smoking, blood pressure, medications, menopausal status, body mass index, and diabetes, hazard ratios for CVD across quartiles 1 to 4 of GlycA were 1.00, 1.10 (95% CI, 0.92 to 1.30), 1.34 (95% CI, 1.13 to 1.58), and 1.64 (95% CI, 1.39 to 1.93), similar to hsCRP, for which hazard ratios were 1.00, 1.18 (95% CI, 0.99 to 1.41), 1.35 (95% CI, 1.14 to 1.61), and 1.75 (95% CI, 1.47 to 2.09) (both Ptrend<0.0001). Associations were attenuated after additionally adjusting for lipids: the hazard ratio of quartile 4 versus 1 for GlycA was 1.23 (95% CI, 1.04 to 1.46; Ptrend=0.002) and for hsCRP was 1.44 (95% CI, 1.20 to 1.72; Ptrend<0.0001). Further adjustment for the other biomarker resulted in a hazard ratio of quartile 4 versus 1 for GlycA of 1.03 (95% CI, 0.85 to 1.24; Ptrend=0.41) and for hsCRP of 1.29 (95% CI, 1.06 to 1.56; Ptrend=0.001).
CONCLUSIONS:
In this prospective study of initially healthy women, baseline GlycA was associated with incident CVD, consistent with a possible role for protein glycans in inflammation and CVD.
CLINICAL TRIAL REGISTRATION URL:
http//clinicaltrials.gov/. Unique identifier NCT00000479.
AuthorsAkintunde O Akinkuolie, Julie E Buring, Paul M Ridker, Samia Mora
JournalJournal of the American Heart Association (J Am Heart Assoc) Vol. 3 Issue 5 Pg. e001221 (Sep 23 2014) ISSN: 2047-9980 [Electronic] England
PMID25249300 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
Copyright© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.
Chemical References
  • Biomarkers
  • Polysaccharides
  • C-Reactive Protein
Topics
  • Age Distribution
  • Aged
  • Biomarkers (blood)
  • C-Reactive Protein (analysis)
  • Cardiovascular Diseases (blood, epidemiology, physiopathology)
  • Confidence Intervals
  • Disease-Free Survival
  • Double-Blind Method
  • Female
  • Glycosylation
  • Humans
  • Incidence
  • Kaplan-Meier Estimate
  • Magnetic Resonance Spectroscopy (methods)
  • Middle Aged
  • Patient Selection
  • Polysaccharides (blood)
  • Predictive Value of Tests
  • Prognosis
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Assessment
  • Severity of Illness Index
  • Survival Rate
  • Women's Health

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