Synthesis, characterization and in vitro evaluation of new composite bisphosphonate delivery systems.

Abstract

In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems.

• Authors: Joanna Kolmas, Marcin Sobczak, Ewa Olędzka, Grzegorz Nałęcz-Jawecki, Cezary Dębek
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 15 Issue 9 Pg. 16831-47 (Sep 22 2014) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 25247580 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biocompatible Materials
• Diphosphonates
• Drug Carriers
• Drug Implants
• Polyurethanes
• Clodronic Acid
• Durapatite

Topics

• Absorbable Implants
• Aliivibrio fischeri (drug effects)
• Biocompatible Materials
• Ciliophora (drug effects)
• Clodronic Acid (administration & dosage)
• Diphosphonates (administration & dosage)
• Drug Carriers (chemical synthesis, toxicity)
• Drug Implants
• Durapatite (toxicity)
• In Vitro Techniques
• Materials Testing
• Microscopy, Electron, Scanning
• Nanoparticles
• Polyurethanes (chemical synthesis, toxicity)
• Porosity
• Tetrahymena thermophila (drug effects)