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Serotonin syndrome following levodopa treatment in diffuse Lewy body disease.

Abstract
Serotonin syndrome results from an acute hyperserotonergic state. It is a rare and potentially fatal complication of drugs that affect the central nervous system serotonin levels. It is characterised by a triad of clinical features comprising altered sensorium, autonomic instability and neuromuscular hyperexcitability, in different combinations. We present an atypical case of serotonin syndrome related to levodopa use in a patient of probable Lewy body dementia. This case highlights the difficulty in diagnosis and management of cases with serotonin syndrome in the absence of history of a known serotonergic drug and the fact that levodopa can contribute to its occurrence.
AuthorsSuman Kushwaha, Akhila Kumar Panda, Hardeep Singh Malhotra, Manmeet Kaur
JournalBMJ case reports (BMJ Case Rep) Vol. 2014 (Sep 22 2014) ISSN: 1757-790X [Electronic] England
PMID25246451 (Publication Type: Case Reports, Journal Article)
Copyright2014 BMJ Publishing Group Ltd.
Chemical References
  • Levodopa
Topics
  • Diagnosis, Differential
  • Humans
  • Levodopa (adverse effects, therapeutic use)
  • Lewy Body Disease (drug therapy)
  • Male
  • Middle Aged
  • Serotonin Syndrome (chemically induced, diagnosis)

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