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Mechanisms of action of fluoridated acidic liquid dentifrices against dental caries.

AbstractOBJECTIVE:
This study attempted to clarify the mechanisms of action of fluoridated acidic liquid dentifrices against dental caries.
DESIGN:
In the in vitro leg, enamel specimens were submitted to a pH-cycling model, treated with distinct dentifrices (0, 550 μgF/g pH 4.5 and pH 7.0, 1100 or 5000 μgF/g pH 7.0) and analyzed using hardness. Alkali-soluble fluoride (F) deposition was quantified on pre-demineralized specimens treated with the dentifrices. In the clinical leg, 2-to-4-year-old children who had been using liquid dentifrices for 6 months (550 μgF/g pH 4.5 or pH 7.0 or 1100 μgF/g pH 7.0) had their plaque samples collected 5 and 60 min after the last brushing. Fluoride uptake in whole plaque was evaluated.
RESULTS:
The reduction of the pH had a partial preventive effect on subsurface hardness loss only. [F] had a significant influence on the deposition of fluoride, surface and subsurface hardness loss. In vivo, the reduction of the pH was able to significantly increase plaque F uptake, leading to similar levels as those found for the neutral dentifrice containing twice [F].
CONCLUSION:
The results obtained from in vitro studies whose design does not include the presence of dental plaque should be interpreted with caution.
AuthorsCristiane de Almeida Baldini Cardoso, Bianca Lacerda, Dayane Franco Barros Mangueira, Senda Charone, Kelly Polido Kaneshiro Olympio, Ana Carolina Magalhães, Juliano Pelim Pessan, Fabiano Vieira Vilhena, Fábio Correia Sampaio, Marília Afonso Rabelo Buzalaf
JournalArchives of oral biology (Arch Oral Biol) Vol. 60 Issue 1 Pg. 23-8 (Jan 2015) ISSN: 1879-1506 [Electronic] England
PMID25244615 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Cariostatic Agents
  • Dentifrices
  • Phosphates
  • fluorophosphate
  • Fluorides
Topics
  • Brazil
  • Cariostatic Agents (chemistry, pharmacology)
  • Child, Preschool
  • Dental Caries (prevention & control)
  • Dentifrices (chemistry, pharmacology)
  • Double-Blind Method
  • Fluorides (pharmacology)
  • Fluorosis, Dental (prevention & control)
  • Hardness
  • Humans
  • Hydrogen-Ion Concentration
  • Infant
  • Phosphates (pharmacology)

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