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Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.

Abstract
Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical cancer suppressor in many cancer cells. It is a master upstream kinase of 13 AMP-activated protein kinase (AMPK)-related protein kinases, and possesses versatile biological functions. LKB1 gene is mutated in many cancers, and its protein can form different protein complexes with different cellular localizations in various cell types. The expression of LKB1 can be regulated through epigenetic modification, transcriptional regulation and post-translational modification. LKB1 dowcnstream pathways mainly include AMPK, microtubule affinity regulating kinase (MARK), salt-inducible kinase (SIK), sucrose non-fermenting protein-related kinase (SNRK) and brain selective kinase (BRSK) signalings, etc. This review, therefore, mainly discusses recent studies about the expression, regulation, downstream signaling and cancer suppressive function of LKB1, which can be helpful for better understanding of this molecular and its significance in cancers.
AuthorsRen-You Gan, Hua-Bin Li
JournalInternational journal of molecular sciences (Int J Mol Sci) Vol. 15 Issue 9 Pg. 16698-718 ( 2014) ISSN: 1422-0067 [Electronic] Switzerland
PMID25244018 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Gonadal Steroid Hormones
  • Molecular Chaperones
  • Tumor Suppressor Proteins
  • Protein Kinases
  • STK11 protein, human
  • Stk11 protein, mouse
  • Protein-Serine-Threonine Kinases
Topics
  • Animals
  • Cell Cycle
  • Cell Death
  • Gene Expression Regulation, Enzymologic
  • Gonadal Steroid Hormones (physiology)
  • Hormesis
  • Humans
  • Mice
  • Mice, Knockout
  • Molecular Chaperones (metabolism)
  • Neoplasm Metastasis
  • Peutz-Jeghers Syndrome (enzymology, genetics)
  • Promoter Regions, Genetic
  • Protein Binding
  • Protein Interaction Mapping
  • Protein Kinases (physiology)
  • Protein Processing, Post-Translational
  • Protein-Serine-Threonine Kinases (deficiency, genetics, metabolism, physiology)
  • Signal Transduction (physiology)
  • Species Specificity
  • Tumor Suppressor Proteins (physiology)

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