| Abstract | Prosthetic heart valves require permanent anticoagulant treatment. In the case of pregnancy, serious problems arise in that coumarin drugs lead to increased incidence of fetal death and malformation. On the other hand, the omission of anticoagulant treatment implies considerable risks of systemic embolism and even of maternal death. Review of the literature and the few cases published so far do not prove that antiplatelet agents are effective and safe and offer sufficient protection against thromboembolism. The use of heparin may reduce the incidence of complications. The authors come to the conclusion that women with prosthetic heart valves should be advised to avoid pregnancy. Biovalves should be applied in those who wish to bear children. |
| Authors | R Dattino, V Niccoli, C Silvestri, M Dattino |
| Journal | La Clinica terapeutica
(Clin Ter)
Vol. 128
Issue 6
Pg. 401-4
(Mar 31 1989)
ISSN: 0009-9074 ITALY |
| Vernacular Title | L'uso degli anticoagulanti in portatrici di protesi valvolari cardiache in gravidanza. |
| PMID | 2524326
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Chemical References |
|
| Topics |
- Abnormalities, Drug-Induced
(etiology)
- Adult
- Bioprosthesis
- Coumarins
(adverse effects, therapeutic use)
- Female
- Fetal Death
(chemically induced)
- Heart Valve Prosthesis
- Heparin
(therapeutic use)
- Humans
- Pregnancy
- Pregnancy Complications, Cardiovascular
(prevention & control)
- Thromboembolism
(prevention & control)
|
