Abstract |
In the present study, the therapeutic effect and underlying mechanism of α-pinene (α-PN) in the ovalbumin (OVA)-sensitized allergic rhinitis (AR) model were investigated. Our results showed that pretreatment with α-PN caused a decrease in clinical symptoms, including a decrease in the number of nasal, eye, and ear rubs, and spleen weight in the OVA-sensitized mice. The level of interleukin (IL)-4 was decreased on the spleen tissue of α-PN treated mice. Pretreatment with α-PN significantly decreased levels of nasal immunoglobulin E. Protein levels of tumor necrosis factor-α, intercellular adhesion molecule-1, and macrophage inflammatory protein-2 were decreased by the administration of α-PN in the nasal mucosa of the OVA-sensitized mice. The increased numbers of eosinophils and mast cells infiltrating the nasal mucosal tissue of mice with AR were decreased following oral administration of α-PN. Post-treatment with α-PN 1h after OVA challenge also resulted in a significant reduction of clinical symptoms and IgE levels. In addition, the expression and phosphorylation of receptor-interacting protein 2 (RIP2) and IκB kinase (IKK)-β and activation of nuclear factor-κB (NF-κB), and caspase-1 were all increased in the activated human mast cell line, HMC-1 cells, however, increased activations of RIP2, IKK-β, NF-κB, and caspase-1 were inhibited by treatment with α-PN. Taken together, we suggest that α-PN is a promising anti-allergic agent and may be useful in the clinical management of AR.
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Authors | Sun-Young Nam, Cha-kwon Chung, Jun-Ho Seo, So-Young Rah, Hyung-Min Kim, Hyun-Ja Jeong |
Journal | International immunopharmacology
(Int Immunopharmacol)
Vol. 23
Issue 1
Pg. 273-82
(Nov 2014)
ISSN: 1878-1705 [Electronic] Netherlands |
PMID | 25242385
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- Anti-Allergic Agents
- Bicyclic Monoterpenes
- Chemokine CXCL2
- Cxcl2 protein, mouse
- Icam1 protein, mouse
- Monoterpenes
- NF-kappa B
- Tumor Necrosis Factor-alpha
- Intercellular Adhesion Molecule-1
- Interleukin-4
- Immunoglobulin E
- RIPK2 protein, human
- Receptor-Interacting Protein Serine-Threonine Kinase 2
- I-kappa B Kinase
- Caspase 1
- alpha-pinene
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Topics |
- Animals
- Anti-Allergic Agents
(therapeutic use)
- Bicyclic Monoterpenes
- Caspase 1
(metabolism)
- Cell Line
- Cell Movement
(drug effects)
- Chemokine CXCL2
(genetics, metabolism)
- Disease Models, Animal
- Eosinophils
(drug effects, immunology)
- Female
- Gene Expression Regulation
(drug effects)
- Humans
- I-kappa B Kinase
(metabolism)
- Immunoglobulin E
(metabolism)
- Intercellular Adhesion Molecule-1
(genetics, metabolism)
- Interleukin-4
(metabolism)
- Mast Cells
(drug effects, immunology)
- Mice, Inbred BALB C
- Monoterpenes
(therapeutic use)
- NF-kappa B
(metabolism)
- Nasal Mucosa
(drug effects, immunology)
- Receptor-Interacting Protein Serine-Threonine Kinase 2
(metabolism)
- Rhinitis, Allergic
(drug therapy)
- Signal Transduction
(drug effects)
- Tumor Necrosis Factor-alpha
(genetics, metabolism)
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