Phosphoinositides and host-pathogen interactions.

Abstract

Phosphoinositides control key cellular processes including vesicular trafficking and actin polymerization. Intracellular bacterial pathogens manipulate phosphoinositide metabolism in order to promote their uptake by target cells and to direct in some cases the biogenesis of their replication compartments. In this chapter, we review the molecular strategies that major pathogens including Listeria, Mycobacterium, Shigella, Salmonella, Legionella and Yersinia use to hijack phosphoinositides during infection. This article is part of a Special Issue entitled Phosphoinositides.

• Authors: Javier Pizarro-Cerdá, Andreas Kühbacher, Pascale Cossart
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1851 Issue 6 Pg. 911-8 (Jun 2015) ISSN: 0006-3002 [Print] Netherlands
• PMID: 25241942 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Bacterial Proteins
• Phosphatidylinositols

Topics

• Actin Cytoskeleton (metabolism, ultrastructure)
• Bacterial Infections (immunology, metabolism, microbiology)
• Bacterial Proteins (genetics, immunology, metabolism)
• Gene Expression
• Host-Pathogen Interactions (immunology)
• Humans
• Legionella (immunology, metabolism)
• Listeria (immunology, metabolism)
• Mycobacterium tuberculosis (immunology, metabolism)
• Phosphatidylinositols (immunology, metabolism)
• Protein Binding
• Salmonella (immunology, metabolism)
• Shigella (immunology, metabolism)
• Transport Vesicles (metabolism)
• Yersinia (immunology, metabolism)