Abstract | OBJECTIVES: METHODS: Twenty-four Sprague-Dawley rats were divided into three groups: control, ESW, ESW + 3-AB groups. All groups except control group were subjected to ESW procedure. ESW + 3-AB group received 20 mg/kg/day 3-aminobenzamide intraperitoneally at 2 h before ESW and continued once a day for consecutive 3 days. The surviving animals were sacrificed at the 4th day and their kidneys were harvested for biochemical and histopathologic analysis. Blood samples from animals were also obtained. RESULTS: Serum ALT and AST levels, serum neopterin and tissue oxidative stress parameters were increased in the ESW group and almost came to control values in the treatment group (p < 0.05, ESW vs. ESW + 3-AB). Histopathological injury score were significantly lower in treatment group than the ESW group (p < 0.05, ESW vs. ESW + 3-AB). CONCLUSION: Our data showed that PARP inhibition protected renal tissue against ESW induced renal injury. These findings suggest that it would be possible to improve the outcome of ESW induced renal injury by using PARP inhibitors as a preventive therapy.
|
Authors | Ercan Malkoc, Bilal Fırat Alp, Zafer Demirer, Ali Guragac, Furkan Dursun, Ferhat Ates, Ibrahim Yildirim, Ramazan Yuksel, Bulent Uysal, Turgut Topal, Yasemin Gulcan Kurt, Ayhan Ozcan, Ahmet Guven |
Journal | Renal failure
(Ren Fail)
Vol. 36
Issue 10
Pg. 1564-9
(Nov 2014)
ISSN: 1525-6049 [Electronic] England |
PMID | 25238491
(Publication Type: Journal Article)
|
Chemical References |
- Benzamides
- Poly(ADP-ribose) Polymerase Inhibitors
- Neopterin
- 3-aminobenzamide
- Glutathione Peroxidase
- Superoxide Dismutase
|
Topics |
- Acute Kidney Injury
(blood, etiology, pathology, prevention & control)
- Animals
- Benzamides
(pharmacology, therapeutic use)
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Glutathione Peroxidase
(metabolism)
- Kidney
(enzymology, pathology)
- Lipid Peroxidation
(drug effects)
- Lithotripsy
(adverse effects)
- Male
- Neopterin
(blood)
- Poly(ADP-ribose) Polymerase Inhibitors
- Random Allocation
- Rats, Sprague-Dawley
- Superoxide Dismutase
(metabolism)
|