[Neuroendocrine carcinoma of the urinary bladder. A case report].

Abstract

BACKGROUND:

Small cell carcinoma of the urinary bladder is an infrequent lesion.

CLINICAL CASE:

We present the case of a 68-year-old male who arrived at the emergency room with a history of 24-h gross hematuria. Imaging studies show a urinary bladder tumor with a 218 cc volume that during a 20-day period increased to 426 cc. Histopathological images with hematoxylin-eosin show an infiltrating solid mass with uneven borders. It is composed of neoplastic cells with evident nuclei predominance and scant cytoplasm (small cells). Chromogranin immunohistochemical staining shows a diffusely positive cytoplasmic granular pattern on neoplastic cells. High molecular weight cytokeratin staining shows a negative pattern on neoplastic cells along with a positive pattern on reporsurrounding normal urothelium. Tumoral mass is positive for synaptophysin and CD-56 and negative for CK-7 and CK-20. Patient therapy was based on radiation plus chemotherapy.

CONCLUSION:

Small cell carcinoma of the urinary bladder represents 0.35-0.70% of urinary bladder tumors. Histological and immunohistochemical identification are key elements in the diagnosis. Treatment approach is based on cisplatin-based chemotherapy plus radical cystectomy, except when metastatic disease is present.

• Authors: Anel Rogelio Aragón-Tovar, Marco Elí Pineda-Rodríguez, Francisco Edgardo Puente-Gallegos, Angel Zavala-Pompa
• Journal: Cirugia y cirujanos (Cir Cir) 2014 May-Jun Vol. 82 Issue 3 Pg. 338-43 ISSN: 2444-054X [Electronic] Mexico
• Vernacular Title: Carcinoma neuroendocrino de vejiga. Reporte de un caso.
• PMID: 25238478 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor
• CD56 Antigen
• Chromogranins
• NCAM1 protein, human
• SYP protein, human
• Synaptophysin
• Keratins

Topics

• Aged
• Biomarkers, Tumor (analysis)
• CD56 Antigen (analysis)
• Carcinoma, Neuroendocrine (chemistry, pathology)
• Carcinoma, Small Cell (complications, pathology)
• Chromogranins (analysis)
• Fatal Outcome
• Hematuria (etiology)
• Humans
• Keratins (analysis)
• Male
• Synaptophysin (analysis)
• Tomography, X-Ray Computed
• Urinary Bladder Neoplasms (chemistry, pathology)