[Use of nimesulide in inflammations of the upper respiratory tract].

Abstract

In a controlled clinical study of 40 patients, aged 18 to 65, suffering from acute inflammatory pathology of the upper respiratory tract or from a chronic form flaring into acute crisis, without any general symptoms of infection, were assigned at random to treatment with nimesulide in tablet form (100 mg x 2/day), or with phenylprenazone in capsules (200 mg x 2/day) for a period of seven days. In both groups a clinically significant reduction of the symptoms was obtained (congestion and edema of the pharyngeal mucosa, cough) as well as an improvement in the values of conductance and MCTt. Epigastralgy was evidenced in three subjects treated with nimesulide and in four treated with phenylprenazone. No significant variations of the laboratory parameters were found in either treatment group.

• Authors: D Passàli, L Bellussi, G Ciferri, I Scaricabarozzi
• Journal: La Clinica terapeutica (Clin Ter) Vol. 128 Issue 2 Pg. 105-11 (Jan 31 1989) ISSN: 0009-9074 [Print] Italy
• Vernacular Title: Impiego della nimesulide nelle flogosi delle vie respiratorie superiori.
• PMID: 2523772 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Sulfonamides
• Feprazone
• Phenylbutazone
• nimesulide

Topics

• Adolescent
• Adult
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Drug Evaluation
• Female
• Feprazone (therapeutic use)
• Humans
• Male
• Middle Aged
• Pharyngitis (drug therapy)
• Phenylbutazone (analogs & derivatives)
• Respiratory Tract Infections (drug therapy)
• Rhinitis (drug therapy)
• Sinusitis (drug therapy)
• Sulfonamides (therapeutic use)
• Tonsillitis (drug therapy)