The association between angiotensin-converting enzyme 2 polymorphisms and essential hypertension risk: A meta-analysis involving 14,122 patients.

Abstract

BACKGROUND:

Some studies have evaluated the associations between the angiotensin-converting enzyme 2 (ACE2) gene polymorphisms and essential hypertension (EH) risk. However, the results remain uncertain. We carried out a meta-analysis to derive a more comprehensive estimation of these associations.

METHODS:

Case-control studies were identified by searching PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI) and Wangfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.

RESULTS:

Significant associations were found between the ACE2 G8790A polymorphism and EH risk in males (OR = 1.27; 95% CI, 1.11-1.44; p = 0.0004; I(2) = 34%) and females (OR = 1.21; 95% CI, 1.09-1.34; p = 0.0003; I(2) = 31%), respectively. Significant associations were also observed between the ACE2 rs2106809 polymorphism and EH risk in males (OR = 1.24; 95% CI, 1.10-1.39; p = 0.0004; I(2) = 18%) and females (OR = 1.39; 95% CI, 1.27-1.51; p < 0.00001; I(2) = 0%), respectively. However, there was no significant association between the ACE2 A1075G polymorphism and EH risk in males (OR = 1.27; 95% CI, 0.77-2.10; p = 0.35; I(2) = 69%) and females (OR = 1.02; 95% CI, 0.83-1.26; p = 0.84; I(2) = 33%), respectively.

CONCLUSIONS:

These results suggest that the ACE2 G8790A and rs2106809 polymorphisms may be associated with EH risk.

• Authors: Mei Yang, Jing Zhao, Lin Xing, Li Shi
• Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS (J Renin Angiotensin Aldosterone Syst) Vol. 16 Issue 4 Pg. 1240-4 (Dec 2015) ISSN: 1752-8976 [Electronic] England
• PMID: 25237167 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: © The Author(s) 2014.

Chemical References

• Peptidyl-Dipeptidase A
• ACE2 protein, human
• Angiotensin-Converting Enzyme 2

Topics

• Angiotensin-Converting Enzyme 2
• Essential Hypertension
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Hypertension (enzymology, genetics)
• Peptidyl-Dipeptidase A (genetics)
• Polymorphism, Single Nucleotide (genetics)
• Risk Factors