Abstract |
A total of 624 consecutive eligible patients undergoing abdominal operations received a single preoperative dose of amoxycillin/clavulanic acid (1.2 g Augmentin) for the prophylaxis of surgical wound infection. They were randomised to have the antibiotic injected intravenously at induction of anaesthesia (n = 328) or infiltrated subcutaneously along the line of the proposed incision (n = 296). The incidence of wound infections was considerably lower in the group given the antibiotic into the abdominal wall (8.4% compared with 15.9%--chi 2 = 7.90, P = 0.005). No significant differences were found in the incidence of other major or minor infective or non-infective postoperative complications between the groups. It is concluded that preincisional intraparietal injection is more effective than intravenous injection of Augmentin for the prophylaxis of surgical wound infection.
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Authors | A V Pollock, M Evans, G M Smith |
Journal | Annals of the Royal College of Surgeons of England
(Ann R Coll Surg Engl)
Vol. 71
Issue 2
Pg. 97-100
(Mar 1989)
ISSN: 0035-8843 [Print] England |
PMID | 2523210
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Clavulanic Acids
- Amoxicillin-Potassium Clavulanate Combination
- Amoxicillin
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Topics |
- Abdomen
(surgery)
- Abdominal Muscles
- Administration, Cutaneous
- Adult
- Amoxicillin
(administration & dosage, pharmacokinetics, therapeutic use)
- Amoxicillin-Potassium Clavulanate Combination
- Clavulanic Acids
(administration & dosage, pharmacokinetics, therapeutic use)
- Clinical Trials as Topic
- Drug Therapy, Combination
(administration & dosage, pharmacokinetics, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Premedication
- Surgical Wound Infection
(prevention & control)
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