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Preincisional intraparietal Augmentin in abdominal operations.

Abstract
A total of 624 consecutive eligible patients undergoing abdominal operations received a single preoperative dose of amoxycillin/clavulanic acid (1.2 g Augmentin) for the prophylaxis of surgical wound infection. They were randomised to have the antibiotic injected intravenously at induction of anaesthesia (n = 328) or infiltrated subcutaneously along the line of the proposed incision (n = 296). The incidence of wound infections was considerably lower in the group given the antibiotic into the abdominal wall (8.4% compared with 15.9%--chi 2 = 7.90, P = 0.005). No significant differences were found in the incidence of other major or minor infective or non-infective postoperative complications between the groups. It is concluded that preincisional intraparietal injection is more effective than intravenous injection of Augmentin for the prophylaxis of surgical wound infection.
AuthorsA V Pollock, M Evans, G M Smith
JournalAnnals of the Royal College of Surgeons of England (Ann R Coll Surg Engl) Vol. 71 Issue 2 Pg. 97-100 (Mar 1989) ISSN: 0035-8843 [Print] England
PMID2523210 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Clavulanic Acids
  • Amoxicillin-Potassium Clavulanate Combination
  • Amoxicillin
Topics
  • Abdomen (surgery)
  • Abdominal Muscles
  • Administration, Cutaneous
  • Adult
  • Amoxicillin (administration & dosage, pharmacokinetics, therapeutic use)
  • Amoxicillin-Potassium Clavulanate Combination
  • Clavulanic Acids (administration & dosage, pharmacokinetics, therapeutic use)
  • Clinical Trials as Topic
  • Drug Therapy, Combination (administration & dosage, pharmacokinetics, therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Premedication
  • Surgical Wound Infection (prevention & control)

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