[Probable side effects caused by plethoryl. Common acute hepatitis, anicteric hepatitis, cirrhosis due to hypervitaminosis A, inflammatory arthralgias].

Abstract

Plethoryl is a combination of triatricol, cyclovalone and vitamin A normally prescribed in the treatment of hypercholesterolaemia. Four cases of side-effects most probably caused by this product are reported. They include: 1) a case of common acute hepatitis, 23 cases of which have already been published, with aggravation and reduced time-lapse after reintroduction; 2) a case of clinically silent but biochemically classical hepatitis; 3) a case of cirrhosis due to vitamin A toxicity; 4) a case of inflammatory arthralgias recurring after the same time-lag when the drug was reintroduced despite double doses and without clinical evidence of hepatitis. The last three side-effects have never been previously reported. The adverse reactions to Plethoryl almost always occur in the unofficial indications of the product, notably in the "treatment" of obesity.

• Authors: B Maroy, P Moullot, J M Constantin
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 18 Issue 11 Pg. 567-70 (Mar 18 1989) ISSN: 0755-4982 [Print] France
• Vernacular Title: Effets secondaires probablement dus au Pléthoryl. Hépatite aiguë habituelle, hépatite anictérique, cirrhose par hypervitaminose A, arthralgies inflammatoires.
• PMID: 2523055 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cyclohexanes
• Cyclohexanones
• Diterpenes
• Drug Combinations
• Triiodothyronine
• Plethoryl
• Vitamin A

Topics

• Acute Disease
• Adult
• Aged
• Aged, 80 and over
• Chemical and Drug Induced Liver Injury (etiology)
• Cyclohexanes (adverse effects)
• Cyclohexanones (adverse effects, therapeutic use)
• Diterpenes
• Drug Combinations (adverse effects, therapeutic use)
• Female
• Humans
• Hypervitaminosis A (complications)
• Liver Cirrhosis (chemically induced)
• Middle Aged
• Obesity (drug therapy)
• Triiodothyronine (adverse effects, analogs & derivatives, therapeutic use)
• Vitamin A (adverse effects, analogs & derivatives, therapeutic use)