Abstract | BACKGROUND: The first therapeutic choice for the treatment of cutaneous sporotrichosis is oral itraconazole; however, the increase in cases of zoonotic transmission outbreak necessitates a search for effective and safe treatment alternatives. OBJECTIVE: METHODS: One hundred and two patients with sporotrichosis diagnosed by isolation of Sporothrix sp. were included and were divided into 2 groups that received different doses of KI: group A received the conventional dose, and group B received the reduced dose. The cure criteria were based on clinical and serological data. RESULTS: Seventy-nine patients (77.4%) reached clinical cure: 70.6% and 84.3% of groups A and B respectively. Sixteen patients (15.6%) were lost during follow-up, and seven changed drug therapy: five in group A and two in group B. The incidence of adverse events was similar for both groups (64.7%): predominantly metallic taste (44%), followed by mild gastrointestinal intolerance and acneiform eruption (10.7% each). No serious adverse events occurred, and there were no recurrences. Analysis of the results showed no statistically significant difference between groups (P = 0.9255). The improvement in serologic titres was significant in both treatment groups. CONCLUSION: Through statistical analysis, the usual posology was not shown to be superior to the one proposed in this study. Serology for sporotrichosis may be used as a valuable tool in the clinical monitoring of these patients.
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Authors | P M Macedo, L M Lopes-Bezerra, A R Bernardes-Engemann, R Orofino-Costa |
Journal | Journal of the European Academy of Dermatology and Venereology : JEADV
(J Eur Acad Dermatol Venereol)
Vol. 29
Issue 4
Pg. 719-24
(Apr 2015)
ISSN: 1468-3083 [Electronic] England |
PMID | 25229626
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 European Academy of Dermatology and Venereology. |
Chemical References |
- Antifungal Agents
- Potassium Iodide
|
Topics |
- Acneiform Eruptions
(chemically induced)
- Adolescent
- Adult
- Antifungal Agents
(administration & dosage, adverse effects)
- Child
- Child, Preschool
- Drug Eruptions
(etiology)
- Female
- Humans
- Male
- Nausea
(chemically induced)
- Potassium Iodide
(administration & dosage, adverse effects)
- Serologic Tests
- Sporothrix
(immunology)
- Sporotrichosis
(drug therapy)
- Taste Disorders
(chemically induced)
- Treatment Outcome
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