Nonspecific reactions to Mycoplasma serum plate antigens induced by inactivated poultry disease vaccines.

Abstract

Nonspecific serum plate agglutination reactions to some avian mycoplasma antigens were induced by injecting chickens with several commercial poultry disease vaccines. All of the vaccines were inactivated, and most of them had oil-emulsion adjuvants. The serum plate agglutination reactions appeared within 2 to 3 weeks post-vaccination and generally persisted for several weeks. The plate test reactions were noted with both Mycoplasma gallisepticum (MG) and M. synoviae (MS) antigens, although the degree and duration of the reactions varied with the vaccine involved and the source of MG and MS plate test antigens. Attempts to prevent the nonspecific reactions by heat-inactivation at 56 C for 30 minutes or by addition of equal volumes of solutions of 2-mercaptoethanol, dithiothreitol, or 3 M sodium chloride were ineffective. No hemagglutination-inhibition activity against MG or MS antigens was induced by the vaccines.

• Authors: H W Yoder Jr
• Journal: Avian diseases (Avian Dis) 1989 Jan-Mar Vol. 33 Issue 1 Pg. 60-8 ISSN: 0005-2086 [Print] United States
• PMID: 2522768 (Publication Type: Journal Article)

Chemical References

• Antigens, Bacterial
• Vaccines, Inactivated

Topics

• Agglutination Tests
• Animals
• Antigens, Bacterial (immunology)
• Chickens (immunology)
• Female
• Mycoplasma (immunology)
• Specific Pathogen-Free Organisms
• Vaccines, Inactivated (immunology)