Abstract | OBJECTIVE: METHODS AND RESULTS: CONCLUSION: Our current data indicate that U II may have promoting effects on the progression of atherosclerosis, likely through suppressing ABCA1 expression via activation of the ERK/NF-κB pathway and reducing cholesterol efflux to promote macrophage foam cell formation.
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Authors | Yan Wang, Jian-Feng Wu, Yan-Yan Tang, Min Zhang, Yuan Li, Kong Chen, Meng-Ya Zeng, Feng Yao, Wei Xie, Xi-Long Zheng, Gao-Feng Zeng, Chao-Ke Tang |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 452
Issue 4
Pg. 998-1003
(Oct 03 2014)
ISSN: 1090-2104 [Electronic] United States |
PMID | 25223800
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- ABCA1 protein, human
- ATP Binding Cassette Transporter 1
- NF-kappa B
- STAT3 Transcription Factor
- STAT3 protein, human
- Urotensins
- urotensin II
- Cholesterol
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Topics |
- ATP Binding Cassette Transporter 1
(metabolism)
- Cell Line
- Cell Proliferation
(drug effects, physiology)
- Cholesterol
(metabolism)
- Down-Regulation
(drug effects, physiology)
- Foam Cells
(cytology, drug effects, physiology)
- Humans
- Lipid Metabolism
(drug effects, physiology)
- MAP Kinase Signaling System
(drug effects, physiology)
- NF-kappa B
(metabolism)
- STAT3 Transcription Factor
(metabolism)
- Signal Transduction
(drug effects, physiology)
- Urotensins
(pharmacology)
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