[Effect of delta sleep-inducing peptide, anticonvulsant preparations and nicotinamide on generalized seizure activity].

Abstract

The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice. It was shown that DSIP increased the latency of first seizure manifestation which were induced by corazol, bicuculline and picrotoxin and also resulted in a suppression of seizure severity of corazol and bicuculline induced seizures. Anticonvulsant action of DSIP was evident under the condition of the mild severity seizures development. The effect of DSIP was mostly pronounced in range of its doses from 10 to 100 mcg/kg. DSIP when combined with phenobarbital, carbamazepine, diphenylhydantoin or nicotinamide enhanced the antiepileptic effects of these anticonvulsant drugs.

• Authors: A A Shandra, L S Godlevskiĭ, A M Mazarati, R F Makul'kin
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 107 Issue 2 Pg. 211-4 (Feb 1989) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie del'ta-sonindutsiruiushchego peptida, protivosudorozhnykh preparatov i nikotinamida na generalizovannuiu sudorozhnuiu aktivnost'.
• PMID: 2522323 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticonvulsants
• Convulsants
• Niacinamide
• Delta Sleep-Inducing Peptide

Topics

• Animals
• Anticonvulsants (therapeutic use)
• Convulsants (pharmacology)
• Delta Sleep-Inducing Peptide (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Niacinamide (therapeutic use)
• Reaction Time (drug effects)
• Seizures (chemically induced, drug therapy)