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Chitosan-alginate membranes accelerate wound healing.

Abstract
The purpose of this study was to evaluate the efficacy of chitosan-alginate membrane to accelerate wound healing in experimental cutaneous wounds. Two wounds were performed in Wistar rats by punching (1.5 cm diameter), treated with membranes moistened with saline solution (CAM group) or with saline only (SL group). After 2, 7, 14, and 21 days of surgery, five rats of each group were euthanized and reepithelialization was evaluated. The wounds/scars were harvested for histological, flow cytometry, neutrophil infiltrate, and hydroxyproline analysis. CAM group presented higher inflammatory cells recruitment as compared to SL group on 2(nd) day. On the 7(th) day, CAM group showed higher CD11b(+) level and lower of neutrophils than SL group. The CAM group presented higher CD4(+) cells influx than SL group on 2(nd) day, but it decreased during the follow up and became lower on 14(th) and 21(st) days. Higher fibroplasia was noticed on days 7 and 14 as well as higher collagenesis on 21(st) in the CAM group in comparison to SL group. CAM group showed faster reepithelialization on 7(th) day than SL group, although similar in other days. In conclusion, chitosan-alginate membrane modulated the inflammatory phase, stimulated fibroplasia and collagenesis, accelerating wound healing process in rats.
AuthorsGuilherme Ferreira Caetano, Marco Andrey Cipriani Frade, Thiago Antônio Moretti Andrade, Marcel Nani Leite, Cecilia Zorzi Bueno, Ângela Maria Moraes, João Tadeu Ribeiro-Paes
JournalJournal of biomedical materials research. Part B, Applied biomaterials (J Biomed Mater Res B Appl Biomater) Vol. 103 Issue 5 Pg. 1013-22 (Jul 2015) ISSN: 1552-4981 [Electronic] United States
PMID25220821 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2014 Wiley Periodicals, Inc.
Chemical References
  • Alginates
  • Hexuronic Acids
  • Membranes, Artificial
  • Glucuronic Acid
  • Chitosan
  • Hydroxyproline
Topics
  • Alginates (pharmacology)
  • Animals
  • Chitosan (pharmacology)
  • Glucuronic Acid (pharmacology)
  • Hexuronic Acids (pharmacology)
  • Hydroxyproline (metabolism)
  • Male
  • Membranes, Artificial
  • Neutrophil Infiltration
  • Neutrophils (metabolism, pathology)
  • Rats
  • Rats, Wistar
  • Wound Healing (drug effects)
  • Wounds and Injuries (metabolism, pathology, therapy)

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