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Targeting tumor invasion: the roles of MDA-9/Syntenin.

AbstractINTRODUCTION:
Melanoma differentiation-associated gene - 9 (MDA-9)/Syntenin has become an increasingly popular focus for investigation in numerous cancertypes. Originally implicated in melanoma metastasis, it has diverse cellular roles and is consistently identified as a regulator of tumor invasion and angiogenesis. As a potential target for inhibiting some of the most lethal aspects of cancer progression, further insight into the function of MDA-9/Syntenin is mandatory.
AREAS COVERED:
Recent literature and seminal articles were reviewed to summarize the latest collective understanding of MDA-9/Syntenin's role in normal and cancerous settings. Insights into its participation in developmental processes are included, as is the functional significance of the N- and C-terminals and PDZ domains of MDA-9/Syntenin. Current reports highlight the clinical significance of MDA-9/Syntenin expression level in a variety of cancers, often correlating directly with reduced patient survival. Also presented are assessments of roles of MDA-9/Syntenin in cancer progression as well as its functions as an intracellular adapter molecule.
EXPERT OPINION:
Multiple studies demonstrate the importance of MDA-9/Syntenin in tumor invasion and progression. Through the use of novel drug design approaches, this protein may provide a worthwhile therapeutic target. As many conventional therapies do not address, or even enhance, tumor invasion, an anti-invasive approach would be a worthwhile addition in cancer therapy.
AuthorsTimothy P Kegelman, Swadesh K Das, Luni Emdad, Bin Hu, Mitchell E Menezes, Praveen Bhoopathi, Xiang-Yang Wang, Maurizio Pellecchia, Devanand Sarkar, Paul B Fisher
JournalExpert opinion on therapeutic targets (Expert Opin Ther Targets) Vol. 19 Issue 1 Pg. 97-112 (Jan 2015) ISSN: 1744-7631 [Electronic] England
PMID25219541 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)
Chemical References
  • SDCBP protein, human
  • Syntenins
Topics
  • Animals
  • Humans
  • Inflammation (metabolism)
  • Neoplasm Invasiveness
  • Neoplasms (metabolism, pathology)
  • Neovascularization, Pathologic (metabolism)
  • Syntenins (metabolism)

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