Abstract | INTRODUCTION:
Melanoma differentiation-associated gene - 9 (MDA-9)/ Syntenin has become an increasingly popular focus for investigation in numerous cancertypes. Originally implicated in melanoma metastasis, it has diverse cellular roles and is consistently identified as a regulator of tumor invasion and angiogenesis. As a potential target for inhibiting some of the most lethal aspects of cancer progression, further insight into the function of MDA-9/ Syntenin is mandatory. AREAS COVERED: Recent literature and seminal articles were reviewed to summarize the latest collective understanding of MDA-9/ Syntenin's role in normal and cancerous settings. Insights into its participation in developmental processes are included, as is the functional significance of the N- and C-terminals and PDZ domains of MDA-9/ Syntenin. Current reports highlight the clinical significance of MDA-9/ Syntenin expression level in a variety of cancers, often correlating directly with reduced patient survival. Also presented are assessments of roles of MDA-9/ Syntenin in cancer progression as well as its functions as an intracellular adapter molecule. EXPERT OPINION: Multiple studies demonstrate the importance of MDA-9/ Syntenin in tumor invasion and progression. Through the use of novel drug design approaches, this protein may provide a worthwhile therapeutic target. As many conventional therapies do not address, or even enhance, tumor invasion, an anti-invasive approach would be a worthwhile addition in cancer therapy.
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Authors | Timothy P Kegelman, Swadesh K Das, Luni Emdad, Bin Hu, Mitchell E Menezes, Praveen Bhoopathi, Xiang-Yang Wang, Maurizio Pellecchia, Devanand Sarkar, Paul B Fisher |
Journal | Expert opinion on therapeutic targets
(Expert Opin Ther Targets)
Vol. 19
Issue 1
Pg. 97-112
(Jan 2015)
ISSN: 1744-7631 [Electronic] England |
PMID | 25219541
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)
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Chemical References |
- SDCBP protein, human
- Syntenins
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Topics |
- Animals
- Humans
- Inflammation
(metabolism)
- Neoplasm Invasiveness
- Neoplasms
(metabolism, pathology)
- Neovascularization, Pathologic
(metabolism)
- Syntenins
(metabolism)
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