[Research on relevance between mitochondrial ATP synthase and malignant tumor].

Abstract

Mitochondrial adenosine triphosphate (ATP) synthase is the key enzyme of mitochondrial oxidative phosphorylation reaction. The down-regulation of the mitochondrial ATP synthase is a hallmark of most human carcinomas, which is the embodiment of the bioenergetic signature of cancer in the performance of the decreased oxidative phosphorylation and increased aerobic glycolysis. Combining with the bioenergetic signature of cancer, studies showed that mitochondrial ATP synthase and multidrug resistance and adverse prognosis of tumor were closely related. Its mechanisms are related to post-transcriptional regulation of the ATP synthase, the hypermethylation of the ATP synthase gene and the inhibitor peptide of the mitochondrial ATP synthase, called ATP synthase inhibitory factor 1 (IF1). In this review, we stress the biological characteristics of mitochondrial ATP synthase and the relationship between ATP synthase and multidrug resistance and prognosis of Malignant tumor, in order to find a new way for tumor therapy.

• Authors: Jingjing Wang, Ruijuan Li, Guangsen Zhang
• Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi (Sheng Wu Yi Xue Gong Cheng Xue Za Zhi) Vol. 31 Issue 3 Pg. 714-7 (Jun 2014) ISSN: 1001-5515 [Print] China
• PMID: 25219263 (Publication Type: Journal Article, Review)

Chemical References

• Adenosine Triphosphate
• Nitric Oxide Synthase
• Mitochondrial Proton-Translocating ATPases

Topics

• Adenosine Triphosphate
• Carcinoma (enzymology)
• Down-Regulation
• Energy Metabolism
• Humans
• Mitochondria (enzymology)
• Mitochondrial Proton-Translocating ATPases (metabolism)
• Neoplasms (enzymology)
• Nitric Oxide Synthase
• Oxidative Phosphorylation