Abstract | BACKGROUND:
IgE-mediated wheat allergy affects around 0.5% of the population, and current management is based on avoidance. We propose an active intervention to promote tolerance in wheat-allergic children. OBJECTIVES: To investigate the efficacy and safety of an oral immunotherapy (OIT) protocol with wheat to treat IgE-mediated wheat-allergic children. METHODS: Six wheat allergic patients assessed in a double-blind, placebo-controlled food challenge (DBPCFC) underwent wheat OIT with an up-dosing phase until 100 g of wheat was tolerated, followed by a 6-month maintenance phase. Tolerance to rye and oat was evaluated, as were specific IgE (sIgE) to wheat and other cereals and sIgE, slgG4, and sIgG1 to a panel of wheat proteins ( alpha-amylase and trypsin inhibitors, wheat lipid transfer proteins, gliadins, and glutenins). RESULTS: Threshold doses in the wheat DBPCFC ranged from 6.6 g to 96.6 g. Five out of 6 (83%) patients successfully finished the up-dosing phase in 3 to 24 days; after a 6-month maintenance phase, all the patients maintained good tolerance of 100 g of wheat daily. Only 6.25% of doses in the up-dosing phase elicited mild adverse reactions. All 5 patients who successfully finished the up-dosing phase tolerated rye after OIT, and all but 1 tolerated oat as well. The median baseline wheat sIgE was 47.5 kU(A)/L, increasing to 84.55 kU(A)/L after up-dosing and decreasing to 28.75 kU(A)/L after 6 months of follow-up. None of the patients showed sIgE to 5-omega-gliadin, but alpha-amylase inhibitors were recognized by all patients. Specific IgG4 and sIgG1 increased in all patients. CONCLUSIONS: Our wheat OIT protocol was safe, efficient, and rapid. In our population, alpha-amylase was the major allergen.
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Authors | P Rodríguez del Río, A Díaz-Perales, S Sanchez-García, C Escudero, Patricia do Santos, M Catarino, M D Ibañez |
Journal | Journal of investigational allergology & clinical immunology
(J Investig Allergol Clin Immunol)
Vol. 24
Issue 4
Pg. 240-8
( 2014)
ISSN: 1018-9068 [Print] Spain |
PMID | 25219106
(Publication Type: Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Administration, Oral
- Child
- Child, Preschool
- Desensitization, Immunologic
(methods)
- Double-Blind Method
- Female
- Humans
- Immunoglobulin E
(immunology)
- Male
- Wheat Hypersensitivity
(immunology, therapy)
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