Preliminary results of MRI-assisted high-dose-rate interstitial brachytherapy for uterine cervical cancer.

Abstract

PURPOSE:

To investigate the effectiveness of our novel MRI-assisted high-dose-rate interstitial brachytherapy for uterine cervical cancer.

METHODS AND MATERIALS:

Between June 2005 and June 2009, 29 previously untreated patients with cervical cancer were enrolled (2 T2b, 2 T3a, 19 T3b, and 6 T4 tumors). We implanted MRI-compatible plastic catheters using our unique ambulatory technique. The total treatment doses were 30-36 Gy (6 Gy per fraction) combined with external beam radiotherapy.

RESULTS:

The median D90 (high-risk clinical target volume), D(2 cc) (bladder), and D(2 cc) (rectum) per fraction were 6.9, 5, and 4.6 Gy, respectively. The 3-year local control rates were 100%, 95%, and 83% for T2, T3, and T4 tumors, respectively. Grade 3 or 4 late complications occurred in 4 patients.

CONCLUSIONS:

Our preliminary evaluation of image-based high-dose-rate interstitial brachytherapy showed favorable local treatment results with an acceptable complication rate.

• Authors: Ken Yoshida, Hideya Yamazaki, Tadashi Takenaka, Tadayuki Kotsuma, Shunsuke Miyake, Mari Mikami Ueda, Mineo Yoshida, Koji Masui, Yasuo Yoshioka, Yasuo Uesugi, Taiju Shimbo, Nobuhiko Yoshikawa, Hiroto Yoshioka, Kazumasa Aramoto, Yoshifumi Narumi, Shigetoshi Yamada, Keiji Tatsumi, Eiichi Tanaka
• Journal: Brachytherapy (Brachytherapy) 2015 Jan-Feb Vol. 14 Issue 1 Pg. 1-8 ISSN: 1873-1449 [Electronic] United States
• PMID: 25218822 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Brachytherapy (adverse effects, methods)
• Female
• Humans
• Magnetic Resonance Imaging (methods)
• Middle Aged
• Organs at Risk (radiation effects)
• Radiation Dosage
• Radiotherapy Dosage
• Radiotherapy Planning, Computer-Assisted (methods)
• Rectum (radiation effects)
• Urinary Bladder (radiation effects)
• Uterine Cervical Neoplasms (radiotherapy)
• Young Adult