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Synthesis and anti-cancer cell activity of pseudo-ginsenoside Rh2.

Abstract
β-d-Glucopyranoside,(3β,12β,20E)-12,25-dihydroxydammar-20(22)-en-3-yl (pseudo-ginsenoside Rh2) and its 20Z-isomer were synthesized from ginsenoside Rh2 under a mild condition, via a simple three-step called acetylation, elimination-addition and saponification. In addition, their activities were evaluated by eight different human tumor cells, compared with ginsenoside Rh2 group. Results indicated that the reaction in the side chain might greatly enhance the anti-proliferative activity of ginsenosides.
AuthorsGuangtao Qian, Zhicai Wang, Jinyu Zhao, Dandan Li, Wei Gao, Baohui Wang, Dayuan Sui, Xiangru Qu, Yanping Chen
JournalSteroids (Steroids) Vol. 92 Pg. 1-6 (Dec 2014) ISSN: 1878-5867 [Electronic] United States
PMID25218677 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Ginsenosides
  • ginsenoside Rh2
Topics
  • Antineoplastic Agents (chemistry)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Ginsenosides (chemical synthesis, chemistry)
  • Humans
  • Molecular Structure

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