HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Immunomodulatory and therapeutic properties of FK-565 in mice.

Abstract
The heptanoyl tripeptide, FK-565 is a biological response modifier with potent therapeutic properties for the treatment of experimental and spontaneous metastases. Doses of FK-565 greater than 5 mg/kg are required for in vivo augmentation of natural killer cells, macrophages, and for therapeutic activity, presumably because FK-565 is a peptide small molecular mass which is rapidly degraded and excreted. Optimal therapeutic activity is observed at approximately 25-50 mg/kg FK-565, administered i.v. three times per week for 4 weeks. In addition to its therapeutic properties, which were consistently greater than the positive control at optimal doses, FK-565 had significant immunoaugmentary properties for natural killer cells, macrophages, and T cells both in vitro and in vivo, suggesting that its therapeutic activity is due to immune augmentation.
AuthorsJ E Talmadge, B Lenz, M Schneider, H Phillips, C Long
JournalCancer immunology, immunotherapy : CII (Cancer Immunol Immunother) Vol. 28 Issue 2 Pg. 93-100 ( 1989) ISSN: 0340-7004 [Print] Germany
PMID2521814 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Adjuvants, Immunologic
  • Antibiotics, Antineoplastic
  • Oligopeptides
  • heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine
Topics
  • Adjuvants, Immunologic (pharmacology, therapeutic use)
  • Animals
  • Antibiotics, Antineoplastic (pharmacology, therapeutic use)
  • Cell Line
  • Cytotoxicity, Immunologic (drug effects)
  • Killer Cells, Natural (drug effects)
  • Lymphocyte Culture Test, Mixed
  • Macrophage Activation (drug effects)
  • Male
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Neoplasm Metastasis
  • Neoplasm Transplantation
  • Neoplasms, Experimental (drug therapy, immunology)
  • Oligopeptides (pharmacology, therapeutic use)
  • T-Lymphocytes, Cytotoxic (drug effects)
  • T-Lymphocytes, Regulatory (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: