Abstract |
Metastasis-associated protein 1 (MTA1) and its short form (MTA1s) regulate the function of estrogen receptors (ERs). Estrogens, via ERs, affect placental growth and fetal development, a process that may involve MTA1 signaling. Expression of MTA1, MTA1s, ERα, and ERβ genes and proteins in rat placentas was studied on 16, 19, and 21 days of gestation (dg). The ERβ messenger RNA decreased significantly toward the end of gestation, whereas its protein level increased in the nuclear fraction on 21 dg. Both MTA1 and MTA1s increased with gestation. Decidual, trophoblast giant, glycogen, and villous trophoblast cells expressed MTA1, ERα, and ERβ proteins on all dg with colocalization of MTA1 with ERα and ERβ in the nucleus and cytoplasm. Expression of MTA1 suggests a possible role in regulating placental functions; considering the repressive function of MTA1 on ERs, the expression of MTA1 suggests that placental cells may be less sensitive to estrogens during late pregnancy.
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Authors | Maie Dawoud Al-Bader, Narayana Kilarkaje, Aseel El-Farra, Abeer Adnan Al-Abdallah |
Journal | Reproductive sciences (Thousand Oaks, Calif.)
(Reprod Sci)
Vol. 22
Issue 4
Pg. 484-94
(Apr 2015)
ISSN: 1933-7205 [Electronic] United States |
PMID | 25217305
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2014. |
Chemical References |
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Mta1 protein, rat
- Proteins
- RNA, Messenger
- Estradiol
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Topics |
- Animals
- Estradiol
(blood)
- Estrogen Receptor alpha
(genetics, metabolism)
- Estrogen Receptor beta
(genetics, metabolism)
- Female
- Gene Expression Regulation, Developmental
- Gestational Age
- Placenta
(cytology, metabolism)
- Pregnancy
- Proteins
(genetics, metabolism)
- RNA, Messenger
(metabolism)
- Rats, Sprague-Dawley
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