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Tubulointerstitial nephritis and uveitis syndrome complicated by IgA nephropathy and Graves' disease: a case report.

AbstractINTRODUCTION:
Tubulointerstitial nephritis and uveitis syndrome is a disorder characterized by a combination of acute tubulointerstitial nephritis and uveitis. Immunoglobulin A nephropathy is defined by the presence of immunoglobulin A deposits in glomerular mesangial areas. In this report, we describe a rare case of tubulointerstitial nephritis and uveitis syndrome complicated by immunoglobulin A nephropathy and Graves' disease, which was successfully treated with corticosteroids. To the best of our knowledge, this is the first time such a case has been documented since tubulointerstitial nephritis and uveitis syndrome was first described.
CASE PRESENTATION:
A 64-year-old Japanese woman presented with tubulointerstitial nephritis and uveitis syndrome accompanied by immunoglobulin A nephropathy and Graves' disease. She had renal dysfunction, proteinuria, and hematuria. Two weeks after her admission, she developed anterior chamber uveitis. She received corticosteroids, resulting in significant clinical improvement.
CONCLUSION:
Tubulointerstitial nephritis and uveitis syndrome is a relatively uncommon cause of tubulointerstitial nephritis. Clinicians should recognize that tubulointerstitial nephritis and uveitis syndrome with immunoglobulin A nephropathy can occur in the presence of Graves' disease. Additionally, this report may provide important clues in terms of the management of a concomitant case of these diseases.
AuthorsYoshinosuke Shimamura, Takahiro Tsushima, Norihito Moniwa, Koichi Hasegawa, Yayoi Ogawa, Hideki Takizawa
JournalJournal of medical case reports (J Med Case Rep) Vol. 8 Pg. 305 (Sep 12 2014) ISSN: 1752-1947 [Electronic] England
PMID25216854 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antithyroid Agents
  • Glucocorticoids
  • Propylthiouracil
  • Prednisolone
  • Methylprednisolone
Topics
  • Antithyroid Agents (therapeutic use)
  • Biopsy
  • Female
  • Glomerulonephritis, IGA (complications, diagnosis, drug therapy)
  • Glucocorticoids (therapeutic use)
  • Graves Disease (complications, drug therapy)
  • Humans
  • Kidney (pathology)
  • Methylprednisolone (therapeutic use)
  • Middle Aged
  • Nephritis, Interstitial (complications, diagnosis, drug therapy)
  • Prednisolone (therapeutic use)
  • Propylthiouracil (therapeutic use)
  • Syndrome
  • Treatment Outcome
  • Uveitis (complications, diagnosis, drug therapy)

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