Abstract | BACKGROUND: METHODS: A nested case-control study of 504 cases and 1,082 controls was conducted using data from the Shanghai Women's Health Study, a large population-based prospective cohort study of 74,941 Chinese women. Urinary PGE-M was measured using a liquid chromatography/tandem mass spectrometric method. Logistic regression estimated odds ratios (OR) and 95% confidence intervals (95% CI) with adjustment for potential confounders. RESULTS: Overall, no association between urinary PGE-M and breast cancer was detected. However, a suggestive positive association was found among postmenopausal women. In particular, a clear dose-response relationship between urinary PGE-M and breast cancer was observed among postmenopausal women with a body mass index (BMI) < 25 kg/m(2) (Plinear trend = 0.005). Among these women, risk of breast cancer increased from 1.00 (reference) to 1.06 (95% CI, 0.56-1.99), 1.50 (95% CI, 0.79-2.83), and 2.32 (95% CI, 1.24-4.41) for the lowest to highest quartiles of PGE-M, and such associations were stronger among those who were diagnosed with cancer within the first four years of sample collection. No apparent association was observed among overweight postmenopausal women (BMI ≥ 25 kg/m(2)). CONCLUSION: High urinary PGE-M level was associated with elevated risk of breast cancer among normal weight, postmenopausal women. IMPACT: Urinary PGE-M level may be useful for breast cancer risk assessment among normal weight, postmenopausal women. Cancer Epidemiol Biomarkers Prev; 23(12); 2866-73. ©2014 AACR.
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Authors | Yong Cui, Xiao-Ou Shu, Yu-Tang Gao, Qiuyin Cai, Bu-Tian Ji, Hong-Lan Li, Nathaniel Rothman, Jie Wu, Gong Yang, Yong-Bing Xiang, Wei Zheng |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 23
Issue 12
Pg. 2866-73
(Dec 2014)
ISSN: 1538-7755 [Electronic] United States |
PMID | 25214156
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | ©2014 American Association for Cancer Research. |
Chemical References |
- Cyclooxygenase 2
- PTGS2 protein, human
- Dinoprostone
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Topics |
- Adult
- Aged
- Breast Neoplasms
(etiology, urine)
- Case-Control Studies
- Cohort Studies
- Cyclooxygenase 2
(adverse effects)
- Dinoprostone
(adverse effects, urine)
- Female
- Humans
- Middle Aged
- Risk Assessment
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