HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site.

Abstract
We have analyzed the effect of the synthetic oligopeptides Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) and Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), analogues to the fibronectin cell-binding sequence, on the formation of experimental lung metastasis. SR-BALB were injected alone or in conjunction with GRGDSP or GRGESP in the tail vein of BALB/c mice. Co-injection with GRGESP reduced by approximately 70% the number of metastatic colonies per mouse. However, co-injection with the closely related peptide GRGDSP, containing the conservative substitution Glu/Asp, did not affect metastatic behavior. GRGESP peptide anti-metastatic activity was not due to a toxic effect on tumor cells or on mice. In vitro adhesion assays testing for a possible effect of the peptide on cell-matrix interactions indicated that the GRGESP peptide did not affect cell adhesion to the matrix proteins tested.
AuthorsS Bretti, P Neri, L Lozzi, M Rustici, P Comoglio, F Giancotti, G Tarone
JournalInternational journal of cancer (Int J Cancer) Vol. 43 Issue 1 Pg. 102-6 (Jan 15 1989) ISSN: 0020-7136 [Print] United States
PMID2521334 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Oligopeptides
  • Receptors, Fibronectin
  • Receptors, Immunologic
  • glycyl-arginyl-glycyl-aspartyl-seryl-proline
  • glycyl-arginyl-glycyl-glutamyl-seryl-proline
Topics
  • Animals
  • Cell Adhesion
  • Cell Line
  • Enzyme-Linked Immunosorbent Assay
  • Fibrosarcoma (pathology)
  • Lung Neoplasms (secondary)
  • Mice
  • Mice, Inbred BALB C
  • Neoplasm Metastasis (prevention & control)
  • Neoplasm Transplantation
  • Oligopeptides (pharmacology)
  • Receptors, Fibronectin
  • Receptors, Immunologic (analysis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: